A Conversation with Cohn on the Activation of CD 4 T Cells

A Conversation with Cohn on the Activation of CD4 T Cells

Despite an agreement on most issues surrounding models for how lymphocytes are activated and inactivated, and arising out of the 1970 Two Signal Model of lymphocyte activation, Cohn and I have different perspectives on two critical issues concerning the activation of CD4 T cells. One issue is the origin of the first effector T helper (eTh) cells, postulated by both of us to be required to optim...

cells invariant NKT + CD 4 engagement by CD 1 d potentiates activation of CD 4

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Changes in Naive CD 4 T Cells

In the elderly, a dramatic shift within the CD4 + T cell population occurs, with an increased proportion having a memory phenotype with markedly decreased responsiveness. To determine what aspects o f the aged phenotype are dependent upon repeated contact with antigen in the environment, we examined CD4 + cells isolated from TC1L Tg n'nce. There is good evidence that no cross-reacting antigens ...

o f CD 4 Lineage T Cells

Thymocytes must bind major histocompatibility complex (MHC) proteins on thymic epithelial cells in order to mature into either CD8 + cytotoxic T cells or CD4 + helper T cells. Thymic precursors express both CD8 and CD4, and it has been suggested that the intracellular signals generated by CD8 or CD4 binding to class I or II M H C , respectively, might influence the fate o f uncommitted cells. H...

T Cells from Naive CD 4 T Cells CD 28 Controls Differentiation of Regulatory